., .

- . -. , , . , , -!

(, , ) [PhsPCHsR'l+X- ( ' = ) 6080% , , [483486]. Ra=CH3, / 2030% [483]. [484] , - 18--6 - . [1634].

- 20% [487].

: ; : . , R*-[485]:

QH.-CHO+ICCIBPPHA+X߻ X NAOH. / . %?

1 6 80

I 6 80

CI 1 70

(= I 60

, , , . , -, ^ . (. [1632]). , . 3.13. ? 1

, %

)

R'CHO+PH,P+CHRRX-(R'-; X-CL BR, I; R>, R'-H, ., .,) R'CHO+RSCHTPPH+X(R',R'=

R'CORN-PH.P+CHR'R'X-(R1, R*-APH\N, H , .; R', ^-, )

ARCOCF,+PH,P+CH,ARCL-+

+PH,P+CH: --+^!NOFLHMEPCBFLAABHIIFI-PHPPLISCHSR'-R. -FARCHO (R1-, ) ARCHO+PH|P+CH2R

×CHSPPHJ+X'+CHJO 2×CHSPPHS+X-+OCH-CHO PH ЗNCR'RR+ PHJCEC=0 (R1, R1. R*-H, CH,, QHJ) ARCOR+

PPH,+-CH-CH-NHARCL-RCHO+R'S-CH(R)-PPH,+CL2090

,0/,1,

BUN+I18--6

-18--6 ,0

82-97

60-

<98

. NAOH

-BUOK CHJCL,

5 . NAOH HJO/CJH,

-

KSCOJ

<93

KF CHJCN 6-18--6 88-Ȼ 1297

NAOH H,0/C,H, CHJCLF - 45-8S 1343,

1375

25%- NIOH HRO/CH. , 7987 1484

, NIOH HJO/CHRC:, R.N+X- 1239

NAOH &, , 45-97 1782

CHJCLJ

ֻ NAOH 80-90 486

. NAOH 1323 487

6585 488

NAOH H,0/CH,C!: 1111

NAOH -. ,0/,1, ~90 1112

-+ (Η×X

(XCN, COOR, COPH, S-PH,

×CHO+ (ETO)SPOCHJX (XSR, SOJR, -SOR) ATCH-CH-CHO+ ETO),POCHJAR

(ETOJSPOCHY-CH- CHAR RRCO+ (ETO)SPOCH2-X FFII, R*-H, , ; X-ON

COOR, )

CH

ARCHO-F (ETO)JPOCHCN

-)-+ (ETO)JPOCH^-PH CHIC0CHTP0<0ET),+CLSHLLCH0

XCHJPO (OET) S+ PHCHO (X-CN, COOR) ARCH.POFOMEJRR-R'R'CO (R'-; R'-H, CH, )

R'CHJ-PO(OC,H,-U.IO)3+RR'CO (R'APIU, , ; RA,R=AJRAN, H, , ) ARSECHSPO(OET)S+ARCHO PHCHCLPO |OF.I),-RWO

KOMI. NAOH . NAOH

. NAOH

. NAOH ػ

NAOH HJO/CHJCIJ NAOH HJO/

50%- NAOH HJO/CH,CL,

/CHJCL,

NAOH HSO/CHRCLJ

KF-2HJO CH3CN

NAH

NAOH

50%- NAOH

, BTUN+I RN+X", -

BINN+IBU4N+I-

BUN+BR

BUN-IBU4N+IBUTN+I- 18--6

15--5 18--6

&UNHSO<

55-95 492. 1256

8587 493.

7281 494, 1457

1360

3077 496, 1114

323 496

1484

1542 1361

1631,

1658

1633

7698

80

81-98

82 39-83

8699

1808 1809

1677

63 44-82

- /, . . ,

, ,

86
< > 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168

" " (6.37Mb)


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