.., .., ..

) , -5 , . , , ( )

ElONa> HN-"N'CR2 H2Q^ HN-^>CR2

(212)

(211) H

J

I R1 Na (210).

HCI -NaCI

(211) - (210), - (212), (211)'

(216) , (203):

> NC-CH2COOMi NHEt2

"'

(213)

NH (215)

M82SQ4 JL

*NI+C-NH2

I J CN NH H

Me^

NaOH/MeOH. N

(214) (MeONa)

N'

Me .

1 Me2SQ4

2 Hp, H+1"

^ Cf^N^ONa

H (216) (203)

KCN>KCI

!

, (, 206), - , (, 217)'

PIvChjCOOEt

Ph-CH2CN

+ EtBr

PWJH2COOEI

C=C-COOEI 150C -CO

Ph-CH(COOEt)2

+ EtOOC-COOEt,, ElOMa -EtOH

+ NH2CONH2^ HNX/LE, + PhCOCIfc Htfl~>

X. -

Ph-CH(COOEt)2 - El

OCH

Ph Et

, -,

5,5- , - . (203) (214) (213), . (214) (215) N- ( ), .

148

(206) 0=C-Ph

(217)

-. , , - . , ( ) &

5.4 6.2.

149

(. . 2.2), (. . 5.4.7) NH2CON(NO)ME. (-, . . 5.4.4), (, . . 4.8), . - , PT, RN, RH, TI, AL, ZN ( , ); , (. . 5.3.2.3). - ( .), (, . . 5.4.9) (, . . 5.4.11). 5- (221). - (218) S- (219). (220) (221):

HN

+ " (219)

F-CH2COOET

EtOCv /

-

Na^EtONa -H2O

H2CS (218)

HI/VF + H2O. HCI ) - MeSH/

CH20

ONa

MeS' "N'

(220) Q

COOK

(222) I J 0*^N

I

H

HN"RF <221 X. 3

I

H

, (222), |3 ( - ).

1970-

52
< > 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63

" " (1.27Mb)


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