.., .., ..

, , 0,--0--, - ( ).

( ) ( ), . , - - . : - (. 6).

- . , (51), $ (52) - (72).

(51) 2,6- , , - (50).

122 (51):

1. n-BuOH,

jj^4] 04> Ij^j 2. NaBHt \\ Me-^hT^Me HOOC^-N^COOH HO^C^NT^CHjOH

(50)

+ Me-NCO

CH20-C-NHMe (51)

, -4: (52), (53) (54), :

.

HTUYCHJOH

Et'1\- R

(56) R = (-CHjCOOHfe

(57) R = .

52"54' Bg (52) R = 2, , (53, R = , , (54, R = CH2NH2,

, () . (, .) (, , ). - (55) - . . , , , - . , - ( ) (56), - -3. - . , (, 57) ( ). .

123

-

6 - (58). , 3---2 (59), 5- (60) ( ). (V) (60) 2- (61), . - , (62). (62) ( ) -, -4 , , , (52). -4 (53). (54):

2

HNQ3

(SB) -

Me'

*0 (59)

+

-

-

-

.CH2NH2

1 NaNC^/HCI,

(62)

(60)

2 HCI(-MeOH), H20

(61)

2 - CH2-NH2

HO^A-CHJOH ^1^ .2

--(52) ^) 2 1 " 154)

(53) >)--0,- (63) - (64). [4+2]-- - 1,4- (65). (66). EKV

ROOC COOR

| 25

MeN - 2

(63)

Me vN' COOR

COOR

CH2OH

COOREIOH

HOJVCOOR -^^

N

[HI

(52)

(65)

HCI

"2 Me^-Nr

(72) - ,

44
< > 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63

" " (1.27Mb)


[]  []  [ ]  [-]  []  [ ]

 

 

kohler

DE CS/1348 BASIL Calligaris
KNSneva.ru - - -, . , .11

.

. . , , . , . , , .

.

- . , , , , , , . , , , , , , , . , , , , , , , . , . , , , . , 1972 .

 

 



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