.., .., ..

. (105) (104) - 20/. (107) N- (104) 103

HNO2

(106) - :

.

2 Mel (PhS02-&Me) Me' ~-NNH2 NHNH2 Me Me N0

1 MeCOCH2COOEt,

Me NMe2

^NH-SC^Na

Ph (103,

Me

NaHSC>3 \_

(102) Ph

Me

1 NaNQ2,HCI, -5J 2 NaHS03, H+"

(104,

"J V +CH2CVHCCOHl V

:ANA0 ME- -N^O

Ph (104)

Ns Me' N'

(107) Ph

2

Me

PI1NO2 (108)

Pd/C FE

COCI

1 "

(101)

. (114) . . - , . - (115) :

Q

(115)

(113) (114)

2-? NH2COi VNH2-C(116)

(116) - (117) - (118), . (119) (115):

* (113).

? 22- -? NH2I

(117)

2^_22^3 ^GR* HOOC^)^OCH2CH2-N3

(119, (115,

? AcHN NHAC (121)

30 , 5-. , , (), - (125) (126). (120) - - (121) . 2- (122) (123), (140 ). N-1 2- (124) (125):

+ _ I N Ni, r-N

N' "Me H (123)

N Me (122)

/ ,

H2N NH2 1

(120)

Br^-Ori) 02N

(124)

1 HN03/H2S04.140,

2 + Y7f Və

104

105

COOEt

Et COOEI ӗ/ * HCOOEI.

1 . 2ΰ,

2 \ +

(- EIOH)

Et COOEt

(127)

,(129)2 *

Et

Et CH2-C-OEt

/\ 1 HCI. 20..

EtOOC(128)CHO

EtOH,

II -N

Et ї<

(131)

(132)

2 SOCI2.

3 CH2N2 2

Ag20. N2

II

2--2

V-/ N .

0=%^ 2 CH2N2 0*<>

(130)

II

Et 2-ї<

"*nJD> * ' H2. OAC 1 W V-NMeCOOH (135)

. , - - (139) (144) - - , , ( -).

(139) 2- (137) 2,6-- (136) . - (138)

106

Me2N

Cl2

(Me2N-C-S-)2 (140)

CICI Me2N=C-CI2 id(141)

T -

NH (144,

NH2 H2NCH2CH2NH2 \_, 2()0c Me2N-C=N-/ ) 2 100Oc>

(143) ) - HNMe2

CI

(147), (139) (144), , . (146) (145). -5. , ^- . (146) , ,

1 KCN,

^'^/N

2 H2N

(146)

Me

NHj

107

- (150) (151) - .

4--2- (148) (149):

Alk Ar-C=0 Alk

HN NH + -=0 -* HN NH (150) Ar = MeS-C^ Alk = Me- .

1(149) (148) 1

(151) Ar = 4-Pyr, Alk = Et,

CH2Ph (152)

(152), .

38
< > 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63

" " (1.27Mb)


[]  []  [ ]  [-]  []  [ ]

 

 


() 32.5 -0.66 (. 200) -

.

. . , , . , . , , .

.

- . , , , , , , . , , , , , , , . , , , , , , , . , . , , , . , 1972 .

 

 



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